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Although the exact mechanism leading to this outcome is undetermined, gene susceptibility and brain infection by several microorganisms has been associated with the pathogenesis of AD, such as for Chlamydophila pneumonie (Grard et al., Borrelia burgdorferi (Miklossy, 2011) and HSV-1 (Itzhaki, 2014, 2016), among others (Lurain et al., 2013

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Visible changes are rare this early

Enhanced expression of transglutaminase 2 in anterior polar cataracts and its induction by TGF- in vitro

However, despite the improvements in folate production by microorganisms that have been achieved, the industrial microbial production of folate is still far from being economically feasible due to very low yields

Smad2 and Smad3 inversely regulate TGF- autoinduction in Clostridium butyricum-activated dendritic cells